Description
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Catalog #
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CAS#
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Target
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Size
|
Price ( $)
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2′,7′-Dichlorofluorescin
Diacetate
H2DCFDA, 2′,7′-
Dichlorodihydrofluorescein
Diacetate
|
SMBC1016
|
4091-99-0
|
Cell-permeable fluorogenic
probe that is useful for the
detection of reactive oxygen
species (ROS) and nitric oxide
(•NO) and for the
determination of the degree of
overall oxidative stress.
|
100
mg
|
50
|
GSK-3 Inhibitor IX
BIO, (2′Z,3′E)-6-
Bromoindirubin-3′-oxime
|
SMBC1017
|
667463-62-9
|
GSK-3α/β
A cell-permeable bis-indolo
(indirubin) compound that acts
as a highly potent, selective,
reversible, and ATP-
competitive inhibitor of GSK-
3α/β (IC50 = 5 nM).
|
1 mg
|
85
|
PRL-3 Inhibitor
1-(2-Bromobenzyloxy)-4-bro
mo-2-benzylidene rhodanine
|
SMBC1021
|
893449-38-2
|
A cell-permeable benzylidene
rhodanine compound that
potently inhibits hPRL-3 (IC50
= 900 nM), a member of the
regenerating liver family
tyrosine phosphatases.
Shown to reduce the
invasiveness of murine
melanoma B16F10 cells.
|
10 mg
|
120
|
Anthrax Lethal Factor
Protease Inhibitor III
5-(5-(2-Chloro-5-trifluoromet
hyl-phenyl)-furan-2-ylmethyle
ne)-4-oxo-2-thioxo-thiazolidin
-3-yl)-acetic acid, BI-11B3
|
SMBC1024
|
259811-62-6
|
A cell-permeable,
rhodanine-acetic acid analog
that chelates the active site
Zn2+ and acts as a potent
inhibitor of anthrax lethal factor
(LF) metalloproteinase (Ki =
32 nM). Has only a minimal
inhibitory effect on MMP-2 and
MMP-9.
|
5 mg
|
135
|
Bisindolylmaleimide I
2-[1-(3-Dimethylaminopropyl
)-1H-indol-3-yl]-3-(1H-indol-3
-yl)-maleimide, GF 109203X,
Gö 6850
|
SMBC1026
|
133052-90-1
|
PKC
A highly selective, cell-
permeable, and reversible
protein kinase C (PKC)
inhibitor (Ki = 10 nM) that is
structurally similar to
staurosporine. Acts as a
competitive inhibitor for the
ATP-binding site of PKC.
Shows high selectivity for
PKCα-, βI-, βII-, γ-, δ-, and ε-
isozymes.
|
1 mg
|
105
|
SB 203580
4-(4-Fluorophenyl)-2-(4-meth
ylsulfinylphenyl)-5-(4-pyridyl)
1H-imidazole
|
SMBC1029
|
152121-47-6
|
P38MAPK
A highly specific, potent, cell-
permeable, selective,
reversible, and ATP-
competitive inhibitor of p38
MAP kinase (IC50 = 34 nM in
vitro, 600 nM in cells). Does
not significantly inhibit the JNK
and p42 MAP kinase at 100
µM. Inhibits IL-1 and TNF-α
production from LPS-
stimulated human monocytes
and the human monocyte cell
line THP-1 (IC50 = 50-100 nM).
|
1 mg
|
55
|
AG 1478
4-(3-Chloroanilino)-6,7-dime
thoxyquinazoline
|
SMBC1030
|
175178-82-2
|
epidermal growth factor
receptor kinase
A cell-permeable, reversible,
ATP-competitive, highly potent
and selective inhibitor of
epidermal growth factor
receptor kinase (IC50 = 3 nM)
versus HER2-neu (IC50 >100
µM) and platelet-derived
growth factor receptor kinase
(IC50 >100 µM).
|
1 mg
|
28
|
AG 1478
|
SMBC1030
|
175178-82-2
|
|
5 mg
|
80
|
PD 169316
4-(4-Fluorophenyl)-2-(4-nitro
phenyl)-5-(4-pyridyl)-1H-imid
azole
|
SMBC1031
|
152121-53
|
p38 MAP kinase
A potent, cell-permeable,
reversible, competitive, and
selective p38 MAP kinase
inhibitor (IC50 = 89 nM).
Inhibition of p38 MAP kinase
by PD 169316 blocks
apoptosis induced by trophic
factor withdrawal in
non-neuronal and neuronal
cell lines.
|
1 mg
|
70
|
PD 169316
4-(4-Fluorophenyl)-2-(4-nitro
phenyl)-5-(4-pyridyl)-1H-imid
azole
|
SMBC1031
|
152121-53
|
p38 MAP kinase
A potent, cell-permeable,
reversible, competitive, and
selective p38 MAP kinase
inhibitor (IC50 = 89 nM).
|
5 mg
|
250
|
7BIO,7-Bromoindirubin-
oxime
(2′Z,3′E)-7-Bromoindirubin-3′
-oxime, Indirubin-3′-
monoxime, 7-Bromo
|
SMBC1028
|
916440-85-2
|
ATP-competitive inhibitor of Flt3
(IC50 = 340 nM) and a
caspase-independent,
non-apoptotic cell death inducer
(IC50 of cell survival ranges from
6.0 µM to 22.0 µM).
|
5 mg
|
discontinued
|
1,3-PBITU, Dihydrobromide
|
SMBC10044
|
|
A cell-permeable, highly potent
human nitric oxide synthase (NOS)
inhibitor that exhibits about 200-fold
higher selectivity for inducible NOS
(Ki = 47 nM) compared to
endothelial NOS (Ki = 9 µM).
|
50 mg
|
70
|
7-Nitroindazole, Sodium Salt
|
SMBC10045
|
|
Inhibitor of nitric oxide synthase in
brain tissue.
|
25 mg
|
75
|
SQ 22536
|
SMBC10046
|
17318-31-9
|
Cell-permeable adenylate cyclase
inhibitor. Blocks PTH-stimulation of
adenylate cyclase (IC50 = 200 µM).
Reduces PGE2-induced inhibition
of O2·– production.
|
5 mg
|
95
|
TCPOBOP
|
SMBC10048
|
76150-91-9
|
The most potent known member of
the phenobarbital-like class of
cytochrome P450 (CYP)-inducing
agents. Acts as a tumor promoter of
murine hepatocarcinogenesis
|
25 mg
|
105
|
D-24851, Indibulin
|
SMBC10049
|
204205-90-3
|
A cell-permeable, potent anticancer
agent that destabilizes
microtubules in tumor cells as well
as in a cell-free system. Binds
directly to tubulin and inhibits
polymerization (IC50 = 300 nM).
|
1 mg
|
140
|
CL 316243 disodium salt
|
SMCUS438
|
151126-84-0
|
Potent and highly selective β3-
adrenoceptor agonist (EC50 = 3
nM); > 10000-fold selective over β1
and β2 receptors.
|
10 mg
|
150
|
CL 316243 disodium salt
|
SMCUS438
|
151126-84-0
|
Potent and highly selective β3-
adrenoceptor agonist (EC50 = 3
nM); > 10000-fold selective over β1
and β2 receptors.
|
50 mg
|
640
|
Filipin III
|
SMCUS463
|
480-49-9
|
A cholesterol binding pentane
macrolide antibiotic
|
500ug
|
100
|
PF 4708671
|
SMCUS422
|
1255517-76-0
|
A membrane permeable p70
ribosomal S6 kinase inhibitor
|
10 mg
|
160
|
Triacsin C
from Streptomyces
aurefaciens
|
SMCUS483
|
76896-80-5
|
A hypotensive vasodilator, inhibitor
of long-chain fatty acid acyl-CoA
synthetase, neutrophils and β-cells
|
1 mg
|
495
|
Cephalosporin C Zinc Salt
|
SMCUS561
|
59143-60-1
|
Cephalosporin C zinc salt is an
antibiotic used to study the effect of
transpeptidase expression,
binding, and inhibition on bacterial
cell wall mucopeptide synthesis.
|
5 G
|
725
|
Orotidine,
Uridine-6-carboxylic acid;
3-Ribofuranosylorotic acid
|
CUS633
|
314-50-1
|
A nucleoside found naturally in
fungi, bacteria and plants
|
5 Mg
|
310
|
