Description
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Catalog #
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CAS#
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Target
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Size
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Price ( $)
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AG 957
4-Amino-N-(2,5-dihydroxybenzyl)methyl benzoate, NSC 654705
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SMBC1046
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A potent tyrosine kinase inhibitor.
Selectively blocks the tyrosine kinase
activity of human p210bcr-abl (Ki = 750 nM)
over p140c-abl (Ki = 10 µM). Also
decreases p210bcr-abl phosphorylation in
viable K562 cells at concentrations and
durations of exposure that also inhibit cell
proliferation
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5 mg
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110
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NF 449
4,4′,4′′,4′′′-[Carbonyl-bis[imino-5,1,3-benzenetriyl bis-(carbonylimino)]]tetrakis-(benzene-
1,3-disulfonic Acid, 8Na)
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SMBC1047
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389142-38-5
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A potent Gsα-subunit-selective G-protein
antagonist. Suppresses the rate of GTPγS
binding to Gsα-s-subunit (IC50 = 140 nM)
but not to Giα-1-subunit. Inhibits
stimulation of adenylate cyclase activity in
S49 cyc- cells (which lack endogenous
Gsα-subunit) by exogenously added Gsα-
subunit.
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10 mg
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150
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Protein Arginine N-Methyltransferase Inhibitor
PRMT Inhibitor, AMI-1
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SMBC1048
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A cell-permeable, symmetrical sulfonated
urea compound that acts as a potent,
specific and non-AdoMet
(S-adenosyl-L-methionine,
SAM)-competitive inhibitor of protein
arginine N-methyltransferases (PRMTs;
IC50 = 8.81 µM for PRMT1 and 3.03 for
yeast-RMT1p) with minimal effect on lysine
methyltransferases. Inhibits nuclear
receptor reporter gene activation in MCF-7
cells, and HIV-1 RT polymerase (IC50 = 5
µM).
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5 mg
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95
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GRAMICIDINE-A,High Purity, Bacillus brevis
gA
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SMBC1050
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11029-61-1
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Naturally-occurring ion channel-forming
pentadecapeptide. The association of two
gA peptides causes the formation of a
monovalent cation-selective ion channel.
Causes K+/H+ exchange in mitochondria
in a non-voltage dependent manner.
Causes red blood cell lysis at 0.5-1.0 µg/ml.
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25 mg
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220
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WY14643
[4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic Acid
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SMBC1051
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50892-23-4
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One of the most potent peroxisome
proliferator-activated receptor α (PPARα)
ligands. Inhibits TNF-α induced expression
of VCAM-1 in endothelial cells. A
hepatocarcinogen and tumor promoter.
Also acts as a potent anti-
hypercholesterolemic agent.
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50 mg
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105
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Guanosine 3′,5′-cyclic Monophosphorothioate, 8-Bromo-, Rp-Isomer, Sodium Salt
Rp-8-Br-cGMPS, Na
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SMBC1052
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A potent, cell-permeable, and metabolically
stable inhibitor of protein kinase G (PKG; Ki
= 4 µM). Acts as a cyclic nucleotide-gated
channel agonist (EC50 = 173.5 µM).
Significantly more lipophilic and
membrane-permeable than cGMP or
Rp-cGMPS.
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5 umol
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425
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ALSTERPAULLONE,
9-Nitro-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one, 9-Nitropaullone, NSC 705701
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SMBC1053
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237430-03-4
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A cell-permeable, potent, reversible, and
ATP competitive inhibitor of GSK-3β (IC50 =
4 nM) and Cdk1/cyclin B (IC50 = 35 nM).
Displays remarkable in vitro antitumor
activity. .
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1 mg
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56
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ALSTERPAULLONE,
9-Nitro-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one, 9-Nitropaullone, NSC 705701
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SMBC1053
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237430-03-4
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A cell-permeable, potent, reversible, and
ATP competitive inhibitor of GSK-3β (IC50 =
4 nM) and Cdk1/cyclin B (IC50 = 35 nM).
Displays remarkable in vitro antitumor
activity. .
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5 mg
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255
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GENISTEIN
Genistein, 7-O-β-D-Glucopyranoside
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SMBC1054
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529-59-9
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An isoflavone glycoside found in soy-based
food products. This is an inactive analog of
the PTK inhibitor Genistein and can be
used as a negative control for Genistein.
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5 mg
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35
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AG 1433
2-(3,4-Dihydroxyphenyl)-6,7-dimethylquinoxaline, HCl, SU 1433
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SMBC1055
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168836-03-1
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A potent, cell-permeable, reversible, and
specific inhibitor of the PDGF-β receptor
kinase (IC50 = 5.0 µM) and of KDR/Flk-
1/VEGF Receptor 2 (IC50 = 9.3 µM). Also
acts as an angiogenesis inhibitor
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5 mg
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105
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AKT INHIBITOR
1L6-Hydroxymethyl-chiro-inositol-2-(R)-2-O-methyl-3-O-octadecyl-sn-glycerocarbonate
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SMBC1058
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A cell permeable, reversible, and substrate
competitive phosphatidylinositol ether
analog that potently and selectively inhibits
Akt (PKB) (IC50 of 5.0 µM). Moderately
inhibits PI 3-K activity (IC50 = 83.0 µM).
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1 mg
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115
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PIFITHRIN A
2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone, HBr
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SMBC1059
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63208-82-2
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A cell-permeable chemical inhibitor of p53.
Reversibly inhibits p53-dependent
transactivation of p53-responsive genes
and reversibly blocks p53-mediated
apoptosis. Inhibits p53-dependent growth
arrest of human diploid fibroblasts in
response to DNA damage but has no effect
on p53-deficient fibroblasts.
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10 mg
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120
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SB 202190
4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole, FHPI
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SMBC1060
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152121-30-7
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A potent, reversible, competitive, and cell-
permeable inhibitor of p38 MAP kinase.
Inhibits p38 phosphorylation of myelin
basic protein (MBP) with no effect on the
activity of the ERK or JNK MAP kinase
subgroups. Also inhibits the kinase activity
of p38β (Ki = 16 nM; IC50 = 350 nM) and
p38 phosphorylation of activating
transcription factor 2 (ATF-2; IC50 = 280
nM).
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5 mg
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65
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SB 202190
4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole, FHPI
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SMBC1060
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152121-30-7
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A potent, reversible, competitive, and
cell-permeable inhibitor of p38 MAP kinase.
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10 mg
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110
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GO 6983
2-[1-(3-Dimethylaminopropyl)-5-methoxyindol-3-yl]-3-(1H-indol-3-yl) maleimide, Go 6983
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SMBC1064
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133053-19-7
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A potent, cell-permeable, reversible, and
ATP-competitive inhibitor of protein kinase
C (PKC) that inhibits several PKC isozymes
(IC50 = 7 nM for PKCα and PKCβ; 6 nM for
PKCγ; 10 nM for PKCδ; and 60 nM for
PKCζ).
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500 μg
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95
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PD153035
AG 1517, 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline, SU 5271, Compound 32
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SMBC1065
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153436-54-5
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An extremely potent, cell-permeamble,
reversible, ATP-competitive and specific
inhibitor of the tyrosine kinase activity of the
epidermal growth factor receptor (EGFR;
IC50 = 25 pM; Ki = 6 pM).
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1 mg
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95
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Tpl2 Kinase Inhibitor
4-(3-Chloro-4-fluorophenylamino)-6-(pyridin-3-yl-methylamino)-3-cyano-[1,7]-naphthyridine
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SMBC100090
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871307-18-5
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A cell-permeable naphthyridine compound
that acts as a potent, reversible, and
ATP-competitive inhibitor of Tpl2 kinase
(IC50 = 50 nM).
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1 mg
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125
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TER14687
(±)-2-N,N-Dimethylaminomethyl-1-indanone, HCl
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SMBC1115
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16931-84-3
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Blocks the association between protein
kinase Cθ-V1 and p59fyn in a yeast
reporter assay. Prevents normal
translocation of PKCθ in T cells.
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10 mg
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150
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Denbufylline
1,3-Di-n-butyl-7-(2′-oxopropyl)xanthine
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SMBC1117
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57076-71-8
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A cell-permeable xanthine derivative that
acts as a selective inhibitor of
phosphodiesterase IV (PDE IV; Ki = ~ 1
µM). Possesses bronchodilatory properties.
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5 mg
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115
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AGL 2043
Tyrphostin AGL 2043, 1,2-Dimethyl-6-(2-thienyl)-imidazolo[5,4-g]quinoxaline
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SMBC1118
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22617-28-8
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A cell-permeable tricyclic quinoxaline
compound that acts as a potent, selective,
ATP-competitive, and reversible inhibitor of
type III receptor tyrosine kinases PDGFR
(IC50 = 800 nM in 3T3 cells; 90 nM against
purified PDGFβ-receptor), Flt3, and Kit
(IC50 = 1-3 µM).
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1 mg
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220
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Trans-2-[3-(4-tert-Butylphenyl)-2-methyl-2-propenylidene]malononitrile
(DCTB)
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SMBC10053
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300364-84-5
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Used as matrix for MALDI-MS
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1 g
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95
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Trans-2-[3-(4-tert-Butylphenyl)-2-methyl-2-propenylidene]malononitrile
(DCTB)
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SMBC10053
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300364-84-5
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Used as matrix for MALDI-MS
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3 g
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260
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