SM Biochemicals LLC
SM Biochemicals provides Life science products for both research and bulk pharmaceutical trials. A
staff with decades of experience in peptide and organic chemistry will help you with the design and
synthesis of your custom peptides and organic molecules and with the technical information necessary
to help you optimize your research results.

Active Pharmaceutical Ingredients ( APIs and Intermediates). Pharmaceutically active peptides

Phone# (714)993-9461 or (925)876-3111 or email at info@smbiochemicals.com.
Fax# (714)-993-9516
Description
Catalog #
CAS#
Target
Size
Price ( $)
Casein Kinase I Inhibitor, D4476
CK1 Inhibitor,
4-(4-(2,3-Dihydrobenzo[1,4]dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl)benzamide
SMBC1066
301836-43-1
A cell-permeable triaryl substituted
imidazolo compound that acts as a
potent, reversible and relatively specific
ATP-competitive inhibitor of CK1 (IC50 =
0.2 µM from S. pombe; 0.3 µM for CK1δ)
and ALK5 (IC50 = 0.5 µM).
1 mg
120
MMP-2/MMP-9 Inhibitor I
(2R)-2-[(4-Biphenylylsulfonyl)amino]-3-phenylpropionic Acid
SMBC1067
193807-58-8
A potent inhibitor of MMP-2 (IC50 = 310
nM) and MMP-9 (IC50 = 240 nM). Orally
active in animal models of tumor growth
and metastasis.
5 mg  
145
Purvalanol A
2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropyl-purine
SMBC1069
212844-53-6
A potent, cell-permeable, reversible, and
selective inhibitor of cyclin-dependent
kinases (Cdks; IC50 = 4 nM for
Cdc2/cyclin B; IC50 = 70 nM for
Cdk2/cyclin A; IC50 = 35 nM for
Cdk2/cyclin E; and IC50 = 75 nM for
Cdk5/p35).
1 mg
60
Purvalanol A
2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropyl-purine
SMBC1069
212844-53-6
A potent, cell-permeable, reversible, and
selective inhibitor of cyclin-dependent
kinases (Cdks; IC50 = 4 nM for
Cdc2/cyclin B; IC50 = 70 nM for
Cdk2/cyclin A; IC50 = 35 nM for
Cdk2/cyclin E; and IC50 = 75 nM for
Cdk5/p35).
5 mg  
120
Cell Sheet Migration Inhibitor, Locostatin
SMBC1071
133812-16-5
A cell-permeable
N-(crotonyl)oxazolidinone compound
that acts as a potent inhibitor of Raf
kinase inhibitor protein (RKIP)/Raf1
kinase interaction. Shown to block
eukaryotic cell migration (IC50 = 14 µM
for inhibition of wound closure in MDCK
cell monolayers) and decrease
formation of lamellipodial protrusions at
the wound margin.
10 mg  
115
PDGFR Tyrosine Kinase Inhibitor III
4-(6,7-Dimethoxy-4-quinazolinyl)-N-(4-phenoxyphenyl)-1-piperazinecarboxamide
SMBC1072
205254-94-0
A cell-permeable piperazinyl-quinazoline
carboxamide compound that acts as a
potent, ATP-competitive, reversible, and
selective inhibitor of PDGF receptor
family of tyrosine kinases (IC50 = 0.05
µM for α-PDGFR; 0.08 µM for β-PDGFR;
0.05 µM for c-Kit; 0.23 µM for Flt3).
1 mg
102
1400W
N-(3-Aminomethyl)benzylacetamidine, 2HCl
SMBC1075
214358-33-5
A selective, cell-permeable, irreversible,
slow, tight-binding inhibitor of inducible
nitric oxide synthase (iNOS; Kd = 7 nM).
Suitable for use in both in vitro and in
vivo systems.
5 mg  
102
TGF-β RI Kinase Inhibitor II
ALK5 Inhibitor II, Transforming Growth Factor-β Type I Receptor Kinase Inhibitor
II, 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
SMBC1076
  A cell-permeable naphthyridinyl pyrazolo
compound that acts as a potent,
selective, reversible, and ATP-
competitive inhibitor of TGF-β type I
receptor (ALK5; IC50 = 23 nM, 4 nM and
18 nM for ALK5 binding, ALK5 auto-
phosphorylation and TGF-β cellular
assay in HepG2 cells, respectively).
1 mg
102
NDSB-256-4T

SB256-4T, SN2564T, 3-(4-tert-Butyl-1-pyridino)-1-propane Sulfonate
SMBC1077
  A non-detergent sulfobetaine (NDSB)
that prevents protein aggregation and
facilitates protein-folding, presumably by
interacting with the early folding
intermediates.
5 gm
128
CL 82198
SMBC1079
  A selective inhibitor of MMP-13 (IC50 =
10 µM). Binds to the S1′ pocket of MMP-
13 with its morpholine ring adjacent to
the catalytic zinc atom.
5 mg  
95
Tranilast
N-(3′,4′-Dimethoxycinnamoyl)anthranilic Acid
SMBC1080
53902-12-8
An anthranilic acid analog that acts as a
potent inhibitor of VEGF- and vascular
permeability factor-induced
angiogenesis and collagen synthesis.
Inhibits VEGF- and PMA-stimulated PKC
activity in retinal capillary endothelial
cells without affecting the VEGF binding
or VEGF receptor phosphorylation.
10 mg  
95
5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole
5,6-Dichlorobenzimidazole Riboside, DRB
SMBC1081
53-85-0
A potent, ATP-competitive, and specific
inhibitor of casein kinase II (IC50 = 6
µM). Reported to inhibit
insulin-stimulated nuclear and cytosolic
p70S6 kinase in CHO cells.
50 mg  
95
BAPTA, Tetrasodium Salt
SMBC1082
126824-24-6
Ca2+ chelator exhibiting a 105-fold
greater affinity for Ca2+ (Kd = 110 nM)
than for Mg2+. After BAPTA complexes
with Ca2+, the UV spectrum shifts from
254 to 279 nm at pH >6.0. Useful for
spectrophotometric monitoring of
extracellular Ca2+ levels, especially
transient phenomena, because of its
insensitivity to pH.
1 gm
110
JNK Inhibitor II, Negative Control
N¹-Methyl-1,9-pyrazoloanthrone
SMBC1088
  A useful negative control for JNK
Inhibitor II (SP600125, Cat. No. 420119).
Inhibits JNK2 and JNK3 only at much
higher concentrations (IC50 = 18 µM
and 24 µM, respectively) compared to
SP600125 (IC50 = 40 nM and 90 nM,
respectively).
1 mg
58
IKK-2 Inhibitor VI
(5-Phenyl-2-ureido)thiophene-3-carboxamide
SMBC1090
354811-10-2
An ureido-thiophenecarboxamide
compound that acts as a potent,
cell-permeable, reversible, and
ATP-competitive inhibitor of IKK-2 (IC50
= 13 nM).
1 mg
120
Compound 56
4-[(3-Bromophenyl)amino]-6,7-diethoxyquinazoline
SMBC1094
171745-13-4
A cell-permeable, reversible,
ATP-competitive, highly potent and
specific inhibitor of the tyrosine kinase
activity of the epidermal growth factor
receptor (IC50 = 6 pM).
500 μg  
140
(±)-Blebbistatin
SMBC1095
674289-55-5
A cell-permeable compound that acts as
a selective, potent, and reversible
inhibitor of nonmuscle myosin II. Inhibits
the ATPase and gliding motility of
human platelets (≤ 100 µM) without
affecting myosin light chain kinase
(MLCK) activity.
5 mg  
145
Cathepsin G Inhibitor I
Z-Phe-Gly-NHO-Bz
SMBC1098
  A potent, selective, reversible,
competitive, non-peptide inhibitor of
cathepsin G [IC50 = 53 nM and Ki = 63
nM].
1 mg
125

SM Biochemicals Offers wide variety of small molecule inhibitors and activators as
Akt inhibtor,CaM Kinase,PTK Inhibitors,PDGFR PTK inhibitors, EGFR-PTK Inhibitors,JAK
PTK inhibitors, JAK3 PTK Inhibitors, SRC family PTK inhibitors,VEGFR PTK Inhibitors,c-Jun
N-terminal Kinase inhibitor,Cdk inhibitors,Casein kinase inhibitor,GSK inhibitors,MAPK
inhibitors,MMP inhibitors,Protein Phosphatase, Protein Kinase C inhibitors,PKC
inhibitors,Rho kinase, inhibitor, PDE1V, other kinase inhibitors, IKK-2 inhibitor,NF-kB
activation inhibitor, antioxidant and free radical scavenger, Nitric oxide synthatase
inhibitors,Phosphodiesterase,adenylate cyclase,ATPase/GTPase inhibtors,DNA and RNA
polymerase,Angiogenesis,MicroRNA miR-122 inhibitors,miR-122 activator,Topoisomerase,
Proteosome and Ubiquitination inhibitors.

Casein Kinase I Inhibitor, D4476, MMP-2/MMP-9 Inhibitor I, PURVALANOL A, Cell Sheet Migration
Inhibitor, Locostatin, PDGFR Tyrosine Kinase Inhibitor III, 1400W, TGF BETA INHIBITOR II, NDSB-256-4T,
CL 82198, TRANILAST, 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole, BAPTA tetrasodium salt,JNK
Inhibitor II, Negative Control, IKK-2 Inhibitor VI, COMPOUND 56, (±)-Blebbistatin , CATHEPSIN G INHIBITOR.
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