Description
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Catalog #
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CAS#
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Target
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Size
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Price ( $)
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FURA 2, Pentasodium Salt
1-[2-(5-Carboxyoxazol-2-yl)-6-aminobenzofuran-5-oxy]-2-(2′-amino-5′-methylphenoxy)-ethane-N,N,N′,N′-
tetraacetic Acid, 5Na
|
SMBC1099
|
|
Most widely used ratiometric calcium
indicator. Highly selective for Ca2+,
however, it does bind other divalent and
trivalent cations. Useful for fluorescence
microscopy.
|
|
inquire
for
bulk
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PD 168393
4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline
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SMBC1100
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194423-15-9
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A potent, cell-permeable, irreversible,
ATP-competitive and selective inhibitor
of EGF receptor (EGFR) tyrosine kinase
activity (IC50 = 700 pM).
|
1 mg
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115
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GO 6976
12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole
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SMBC1101
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136194-77-9
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A cell-permeable, reversible, and ATP-
competitive inhibitor of protein kinase C
(PKC; IC50 = 7.9 nM for rat brain).
Selectively inhibits Ca2+-dependent
PKC α-isozyme (IC50 = 2.3 nM) and
PKCβI (IC50 = 6.2 nM).
|
500 μg
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130
|
UCH-L3 Inhibitor
Ubiquitin Thiolesterase L3 Inhibitor, 4,5,6,7-Tetrachloroindan-1,3-dione
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SMBC1102
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30675-13-9
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A 1,3-indanedione compound that acts
as a selective and potent inhibitor of
UCH-L3 (IC50 = 0.6 µM) with ~125-fold
greater selectivity over UCH-L1 (IC50 =
75 µM).
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10 mg
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100
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NF-κB Activation Inhibitor II, JSH-23
4-Methyl-N¹-(3-phenylpropyl)benzene-1,2-diamine
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SMBC1103
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749886-87-1
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A cell-permeable diamino compound
that selectively blocks nuclear
translocation of NF-κB p65 and its
transcription activity (IC50 = 7.1 µM in a
NF-κB reporter assay using RAW 264.7)
without affecting IκB degradation.
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5 mg
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120
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PD 150606
3-(4-Iodophenyl)-2-mercapto-(Z)-2-propenoic Acid
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SMBC1104
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426821-41-2
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A cell-permeable, non-competitive,
selective non-peptide calpain inhibitor
[Ki = 210 nM for calpain-1and 370 nM for
calpain-2 directed towards the calcium
binding sites of calpain.
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5 mg
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100
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Necrostatin-5
3-p-methoxyphenyl-5,6-tetramethylenothieno[2,3-d]pyrimidin-4-one-2-mercaptoethylcyanide,
2-[[3,4,5,6,7,8-hexahydro-3-(4-methoxyphenyl)-4-oxo[1]benzothieno[2,3-d]pyrimidin-2-yl]thio]-acetonitrile
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SMBC1105
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337349-54-9
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Necrostatin-5 is an inhibitor of
necroptosis (non-apoptotic cell death
pathway) by indirect inhibition of RIP1
kinase. Necroptosis is defined as
alternative active cell death pathway:
Death-Domain Receptor (DRs, e.g.
Fas/TNFR) mediated and
caspase-inhibitor insensitive with
specific morphology (nuclear
condensation, organelle swelling, loss
of plasma membrane integrity).
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25 mg
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190
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GSK-3β Inhibitor I
TDZD-8, 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
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SMBC1106
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327036-89-5
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A thiadiazolidinone (TDZD) analog that
acts as a highly selective, non-ATP
competitive inhibitor of GSK-3β (IC50 = 2
µM). Inhibits Flt-3 and PKC activities
(IC50 = 673 nM and 1.4-5.5 µM,
respectively)
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5 mg
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80
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Phosphodiesterase V Inhibitor II
PDE V Inhibitor II
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SMBC1107
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|
A cell-permeable tetrahydro-β-carboline-
hydantoin compound that acts as a
potent and highly selective
phosphodiesterase V inhibitor (IC50 = 5
nM for bovine aorta PDE V; IC50 > 10 µM
for human recombinant PDE I & III, and
for bovine aorta PDE II & IV].
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5 mg
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100
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FTI-276 trifluoroacetate salt
N-[4-[2-(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl]methionine trifluoroacetate salt
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SMBC1108
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170006-72-1
(free base)
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FTI-276 is a highly potent RasCAAX
peptidomimetic. FTI-276 antagonizes
both H and K-Ras oncogenic signaling.
It is an inhibitor of farnesyltransferase
(Ftase) in vitro with an IC50 of 500 pM
and is an anti-cancer agent.
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5 mg
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390
|
RRD-251 hydrochloride
2-(2,4-Dichlorobenzyl)-2-thiopseudourea hydrochloride, Rb/Raf-1 disruptor 251 hydrochloride,
S-(2,4-Dichlorobenzyl)-isothiouronium hydrochloride, (2,4-Dichlorophenyl)carbamimidothioic acid
methyl ester hydrochloride
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SMBC1109
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72214-67-6
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RRD-251 hydrochloride is a reversible,
potent, and selective disruptor of
Rb/Raf-1 interaction. The retinoblastoma
tumor suppressor protein (Rb) controls
the G1-S boundary by repressing the
transcriptional activity of the E2F family of
transcription factors.
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25 mg
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110
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RNA Polymerase III Inhibitor
ML-60218,
N-[1-(3-(5-Chloro-3-methylbenzo[b]thiophen-2-yl-1-methyl-1H-pyrazol-5-yl)]-2-chlorobenzenesulfonamide
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SMBC1110
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577784-91-9
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A cell-permeable indazolo-sulfonamide
compound that displays broad-spectrum
inhibitory activity against RNA
Polymerase III (IC50 = 27 and 32 µM for
human and S. cerevisiae RNA Pol III,
respectively).
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10 mg
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230
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GSK-3 Inhibitor X
BIO-Acetoxime, (2′Z,3′E)-6-Bromoindirubin-3′-acetoxime
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SMBC1111
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740841-15-0
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An acetoxime analog of BIO, GSK-3
Inhibitor IX that exhibits greater selectivity
for GSK-3α/β (IC50 = 10 nM) over
Cdk5/p25, Cdk2/A and Cdk1/B (IC50 =
2.4 µM, 4.3 µM and 63 µM, respectively).
|
1 mg
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95
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PTP Inhibitor III
α-Bromo-4-(carboxymethoxy)acetophenone, 4-(Carboxymethoxy)phenacyl Br, Protein Tyrosine
Phosphatase Inhibitor III
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SMBC1112
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29936-81-0
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A potent, cell-permeable, and covalent
protein tyrosine phosphatase (PTP)
inhibitor. Binds to SHP-1 (ΔSH2), the
catalytic domain of the SH2 domain-
containing phosphatase SHP-1
|
10 mg
|
130
|
Wnt Agonist
2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine, Wnt Pathway Activator I
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SMBC1113
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853220-52-7
|
A cell-permeable pyrimidine compound
that acts as a potent and selective
activator of Wnt signaling without
inhibiting the activity of GSK-3β (IC50 >
60 µM).
|
5 mg
|
155
|
AGL 2263
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SMBC1114
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638213-98-6
|
A cell-permeable
benzoxazolone-containing bioisostere of
tyrphostin AG 538 (Cat. No. SMBC1041)
that acts as a potent,
substrate-competitive, but not
ATP-competitive, inhibitor of insulin
receptor (IR) and insulin-like growth
factor-1 receptor (IGF-1R).
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1 mg
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60
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AGL 2263
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SMBC1114
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638213-98-6
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5 mg
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165
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N-(4-Hydroxyphenylpropanoyl)spermine. 3 HCl
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SMBC1119
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130631-59-3
|
Potent glutamate antagonist
Wasp toxin analog. More potent than
PhTX-343 at locust NMJ. Antagonist of
the quisqualate-sensitive L-glutamate
receptor (quis-GluR) of locust muscle
|
250 µg
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115
|
ENMD 547
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SMBC1120
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644961-61-5
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PAR-2 Antagonist.
A selective PAR-2 antagonist. Dose
dependently inhibits calcium signaling
in Lewis lung carcinoma cells
stimulated with a soluble peptide PAR-2
agonist or trypsin, but not with a soluble
PAR-1 agonist. Does not inhibit platelet
aggregation stimulated
|
20 mg
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125
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Trans-2-[3-(4-tert-Butylphenyl)-2-methyl-2-propenylidene]malononitrile (DCTB)
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SMBC1121
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300364-84-5
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Matrix substance for MALDI-MS
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1 g
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115
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JAK Inhibitor I
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SMBC10014
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457081-03-7
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JAK PTK Inhibitor
Janus protein tyrosine kinases (JAKs).
Displays potent inhibitory activity against
JAK1 (IC50 = 15 nM for murine JAK1),
JAK2 (IC50 = 1 nM), JAK3 (Ki = 5 nM),
and Tyk2 (IC50 = 1 nM).
|
500 μg
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95
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