Description
|
Catalog #
|
CAS #
|
Target
|
Size
|
Price
($)
|
KN-92
|
SMBC10030
|
176708-42-2
|
ACa2+/CaM kinase II inhibitor. Useful as a
negative control for KN-93
|
1 mg
|
105
|
KN-62
|
SMBC10031
|
127191-97-3
|
A cell-permeable, reversible, and selective
inhibitor of CaM kinase II (Ki = 900 nM for
rat brain CaM kinase II) that binds directly
to the calmodulin binding site of the
enzyme.
|
1 mg
|
96
|
Brc-abl Inhibitor
(3-(6)-(4-Trifluoromethoxy-phenylamino)-pyrimidin-4-yl)-benzamide,
GNF-2
|
SMBC10032
|
778270-11-4
|
A cell-permeable and reverisble
pyrimidine compound that binds to the
c-abl myristoyl binding pocket and acts as
an allosteric, non-ATP-competitive
inhibitor of cellular Bcr-abl activity and
Bcr-abl-dependent cellular functions.
Exhibits potent and selective
antiproliferative activity toward
Bcr-abl-expressing cells (IC50 = 138 nM,
194 nM, 268 nM and 273 nM in
Ba/F3.p210, Ba/F3.p185Y253H, SUP-B15
and Ba/F3.p210E255V, and K562,
respectively).
|
5 mg
|
120
|
PD 158780
|
SMBC10033
|
171179-06-9
|
A potent, cell-permeable, reversible,
ATP-competitive inhibitor of the EGFR
tyrosine kinase activity (IC50 = 8 pM). Also
inhibits heregulin-stimulated
autophosphorylation in SK-BR-3 (IC50 =
49 nM) and MDA-MB-453 (IC50 = 52 nM)
breast carcinomas.
|
10 mg
|
135
|
VEGFR Tyrosine Kinase Inhibitor V
|
SMBC10034
|
|
A cell-permeable, ATP-binding
pocket-targeting
N-cyclopropylnaphthamide compound that
acts as a potent inhibitor against
VEGFR1/2/3 (IC50 = 0.6 nM against
VEGFR2), c-FMS, RET, Lyn, and c-KIt,
while exhibiting much reduced activity
against 36 other commonly studied
kinases.
|
5 mg
|
155
|
JNK Inhibitor II
|
SMBC10035
|
129-56-6
|
A potent, cell-permeable, selective, and
reversible inhibitor of c-Jun N-terminal
kinase (JNK) (IC50 = 40 nM for JNK-1 and
JNK-2 and 90 nM for JNK-3). The
inhibition is competitive with respect to
ATP. Exhibits over 300-fold greater
selectivity for JNK as compared to ERK1
and p38-2 MAP kinases.
|
5 mg
|
50
|
JNK Inhibitor II
|
SMBC10035
|
129-56-6
|
A potent, cell-permeable, selective, and
reversible inhibitor of c-Jun N-terminal
kinase (JNK) (IC50 = 40 nM for JNK-1 and
JNK-2 and 90 nM for JNK-3). The
inhibition is competitive with respect to
ATP. Exhibits over 300-fold greater
selectivity for JNK as compared to ERK1
and p38-2 MAP kinases.
|
25 mg
|
170
|
WHI-P180, Hydrochloride
|
SMBC10036
|
211555-08-7
|
A potent inhibitor of lgE-mediated mast
cell responses to allergens in vitro and in
vivo. Also inhibits cyclin-dependent kinase
2 (Cdk2; IC50 = 1 µM) by blocking the ATP
site.
|
500
μg
|
75
|
WHI-P180, Hydrochloride
|
SMBC10036
|
211555-08-7
|
A potent inhibitor of lgE-mediated mast
cell responses to allergens in vitro and in
vivo. Also inhibits cyclin-dependent kinase
2 (Cdk2; IC50 = 1 µM) by blocking the ATP
site.
|
1 mg
|
125
|
cdk2/5 Inhibitor
|
SMBC10037
|
|
An aminopyrimidine derivative that acts as
a selective and ATP-competitive inhibitor
of Cdk2/cyclin E and Cdk5/p25 (Ki = 2 µM).
Binds to the ATP-binding pocket of Cdk2.
|
5 mg
|
95
|
SB 202474
4-Ethyl-2(p-methoxyphenyl)-5-(4′-pyridyl)-IH-imidazole
|
SMBC10038
|
172747-50-1
|
A negative control for SB202190 and
SB203580 in p38 MAP kinase inhibition
studies.
|
1 mg
|
110
|
MMP-2 Inhibitor II
(4-(4-(Methanesulfonamido)phenoxy)phenylsulfonyl)methyloxirane
|
SMBC10039
|
869577-51-5
|
An oxirane analog of SB-3CT, pMS that
acts as a selective, active site-binding,
irreversible inhibitor of MMP-2 (Ki = 2.4
µM). Although less potent, it exhibits
enhanced selectivity towards MMP-2 (Ki =
45 and 379 µM for MMP-1 and MMP-7,
respectively) than SB-3CT, pMS.
|
5 mg
|
145
|
PTP Inhibitor I
|
SMBC10040
|
2491-38-5
|
A potent, cell-permeable, and covalent
protein tyrosine phosphatase (PTP)
inhibitor. Inhibits SHP-1 (ΔSH2), the
catalytic domain of the SH2 domain-
containing phosphatase SHP-1 (Ki = 43
µM), and PTPIB (Ki = 42 µM).
|
10 mg
|
120
|
Bisindolylmaleimide I .HCl
|
SMBC10041
|
176504-36-2
|
A reversible and ATP-competitive inhibitor
of protein kinase C (Ki = 10 nM). May
inhibit protein kinase A at much higher
concentrations (Ki = 2 µM).
|
1 mg
|
95
|
K-252c
|
SMBC10042
|
85753-43-1
|
A cell-permeable, reversible, and
ATP-competitive inhibitor of protein kinase
C (IC50 = 2.45 µM) and protein kinase A
(IC50 = 25.7 µM).
|
1 mg
|
95
|
Rho Kinase Inhibitor
|
SMBC10043
|
|
A cell-permeable
isoquinolinesulfonamide compound that
acts as a highly specific, reversible,
potent, and ATP-competitive inhibitor of
G-protein Rho-associated kinase (ROCK;
Ki = 1.6 nM).
|
1 mg
|
160
|
Rho Kinase Inhibitor
|
SMBC10043
|
|
A cell-permeable
isoquinolinesulfonamide compound that
acts as a highly specific, reversible,
potent, and ATP-competitive inhibitor of
G-protein Rho-associated kinase (ROCK;
Ki = 1.6 nM).
|
5 mg
|
350
|
